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HumanNet-PI (Protein-protein Interaction network)HumanNet-FN (Functional gene network)HumanNet-XC (Functional gene network extended by Co-citation) Step 2. Select your analysis. Network-based disease gene prediction You may predict novel candidate genes for diseases (or biological processes) of your interest.
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HumanNet – Probabilistic Functional Gene Network of H.sapiens. About HumanNet | HumanNet Search | Batch Downloads.
The fourth level network, HumanNet-XN, is a fully extended functional gene network by both co-citation and interologs. Interologs derived from non-human species provided 101 036 more links to HumanNet-XC, yet its genome coverage only increased from 94.6 to 95.3%. The most comprehensive network, HumanNet-XN, contains 17 929 genes and 525 537 links.
HumanNet now comprises a hierarchy of human gene networks, allowing for more flexible incorporation of network information into studies. HumanNet performs well in ranking disease-linked gene sets with minimal literature-dependent biases. We observe that incorporating model organisms’ protein-protein interactions does not markedly improve …
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Nov 8, 2021HumanNet-PI consists of physical interactions only. Therefore, users who wish to study protein complexes or ligand-receptor interactions may utilize HumanNet-PI. HumanNet-FN is an integrated functional gene network encompassing associations between human genes derived via diverse computational and experimental approaches, including a PI network.
34747468. HumanNet v3: an improved database of human gene networks for disease research. [PMID: 34747468] Kim CY, Baek S, Cha J, Yang S, Kim E, Marcotte EM, Hart T, Lee I. Abstract. Network medicine has proven useful for dissecting genetic organization of complex human diseases. We have previously published HumanNet, an integrated network of …
HumanNet – About HumanNet. a probabilistic functional gene network of 18,714 validated protein-encoding genes of Homo sapiens (by NCBI March 2007), constructed by a modified Bayesian integration of 21 types of ‘omics’ data from multiple organisms, with each data type weighted according to how well it links genes that are known to function …
HumanNet-XI contains 17 303 genes and 418 525 links. The fourth level network, HumanNet-XN, is a fully extended functional gene network by both co-citation and interologs. Interologs derived from non-human species provided 101 036 more links to HumanNet-XC, yet its genome coverage only increased from 94.6 to 95.3%.
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Jan 7, 2022Users can select a suitable tier of HumanNet for their study purpose. We showed that on disease gene predictions, HumanNet v3 outperforms both the previous HumanNet version and other integrated human gene networks. Furthermore, we demonstrated that HumanNet provides a feasible approach for selecting host genes likely to be associated with COVID-19.
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